Recently acknowledged as a powerful anti cancer agent by the US National Cancer Institute, CBD (Cannabidiol) oil is now being used actively by medical professionals to fight cancer. Derived from the Cannabis plant, CBD, as compared to THC, is non-psychoactive in nature and has been proven to kill cancerous cells.
Let us take a closer look at how natural CBD oil helps fight cancer and see what evidence is there that shows that this is an effective remedy to kill cancerous cells in the body.
How CBD Oil Fights Cancer?
Every cell in our body has inter-convertible sphingolipids. The inter-convertible sphingolipids are responsible for managing the life and death of the cells. In other words, this can be described as Sphingolipid Rheostat. When endogenous ceramide, which is sphingosine 1 phosphate’s signaling metabolite, becomes high, it causes apoptosis (cell death). However, when ceramide is low, it makes the cells stronger.
When therapeutic amount of CBD and THC is taken over time, it leads to the shift in mitochondria and eventually results in cell death as the mitochondrion are responsible for producing energy for the cells. How this works is that as ceramide begin to accumulate in the cell, it simultaneously starts to increase the permeability of the mitochondrial membrane pore to cytochrome-C (an essential protein used for energy synthesis). When Cytochrome-C is pushed out of the mitochondria, it kills the energy source of the cell.
Additionally, the increase in ceramide in the cell also results in geno-toxic stress in the nucleus of the cancerous cell. This generates p53. It is a protein that disrupts metabolism of calcium in mitochondria. Besides this, the high ceramide levels also disrupt cellular lysosome. This is the digestive system of the cell that provides essential nutrients to the cell for proper functioning. Keeping all this in consideration, the high levels of ceramide leaves practically no possibility of cancerous cell survival in the body.
Studies also show that CBD cannabinoids and THC hijack lipoxygenase. This helps inhibit and stop tumor growth, ensuring that the cancer doesn’t spread.
CBD Oil as Potential Anti Cancer Drug – What Research Shows?
Over the decade numerous research studies have been conducted to identify CBD oil’s effectiveness as a powerful anti cancer drug. Here’s a look at what different research studies say about this drug:
According to a research paper published and released by the AACR (American Association for Cancer Research), CBD oil has the potential to inflict PCD (Programmed Cell Death) in cancer cells in the breast. (1)
It’s unfortunate but true that breast cancer is reported as the 2nd leading cause of death among women in the US. Since conventional methods to treat cancer are limited by acquired resistance or toxicity, medical professionals are now looking for novel agents for the treatment of cancer. The paper published by the ACCR illustrated that during research; CBD acted as a potent with a reported activity in the cancerous cell lines.
Simultaneously, it elucidated its positive effects on the neo-plastic pathway. The paper showed that CBD stopped the survival of both positive as well as negative estrogen receptors in the cell lines and led to cell death. More importantly, CBD had a very small effect on mammary cells. The research paper suggested that CBD helped kill cancerous cells and minimized the damage done to normal tissues of the breast.
Another cancer and CBD research conducted by the British Journal of Pharmacology demonstrated similar research results. It showed that CBD had the potential to inhibit the growth of breast cancer cells. The study also indicated that the use of CBD helped reduce the risk of nerve damage and even eased the neuropathic pain induced by chemotherapy. This benefit of CBD is worthy of mentioning because chemotherapy induced pain can be unbearable and overwhelming for late stage cancer patients. Due to the immense pain, many patients often stop chemotherapy and end up losing their battle against cancer. (2)
This research truly provides hope to patients battling with cancer. Decrease in pain during chemotherapy can help patients continue their treatment successfully and increase their chances of resuming their normal life.
Based on the impressive research results of CBD on dealing with cancer, studies are being carried actively on CBD and cancer worldwide. Here’s a look at what Germans have concluded about CBD and how it helps fight cancer:
A study conducted by a team of German researchers in 2014 on CBD and Lung Cancer published in Biochemical Pharmacology journal showed how CBD made cancerous cells susceptible by breaking them down and killing the tumor. (3)
The study revealed that CBD provides a milder cancer treatment as compared to approaches like Chemotherapy. Nonetheless, the results are effective. The research study provides good evidence on how CBD not only inhibits the spread of cancer but also causes death of cancerous cells.
According to the study performed by German researchers, cannabinoids increased the expression of ICAM-1 (intercellular adhesion molecule 1). The increase in ICAM-1 helped fight both the invasiveness and also the spread of cancerous cells in the lungs. The study particularly showed how the increase in ICAM 1 affected cancer cells via LAK (lymphokine Activated Killer) cells. LAK are basically white blood cells which are stimulated to kill tumors.
The study highlighted that Cannabidiol increased ICAM 1 on cancerous cells in the lungs which helped increase susceptibility of the cells to LAK cell mediated cytolysis (breaking-down of cells).
What Can We Conclude?
In conclusion, it can be said that CBD offers hope to patients suffering from cancer. When it comes to treating cancer, CBD’s impressive medicinal benefits and positive results leave patients and medical professionals thinking that the day is not far when cancer will be treated easily and patient survival rate will increase dramatically.